Unexpectedly, his wife’s pregnancy was unexpectedly caused by antibiotics!

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Introduction: Recently, a study published in BMJ evidence -based medicine magazines showed that the use of antibiotic drugs for common use of antibiotics may reduce the effect of hormone contraceptives, which eventually led to a significant increase in unexpected pregnancy risks.

At present, the related medication pays attention to the blank blank

At present, although there are cases of women who take hormone contraceptives after taking a course of antibiotics, they have reported pregnancy after taking an antibiotic of antibiotics, and the efficacy of whether the use of antibiotics will reduce the use of antibiotics will still be concluded.Therefore, it is generally believed that the two will not produce drug interactions and cause contraceptive failure, and of course medical staff will not give patients special drug guidance.

This means that women who choose to use hormone contraceptives will no longer use additional contraceptive measures even if they take antibiotics, but this study indicates that in this context, the risk of unexpected pregnancy will not be ruled out.

Researchers used the database of British drugs and health product supervision agencies to search for the adverse reaction report from 1963 to July 2018, which involved information between drugs and accidental pregnancy in these reports.

Drugs are divided into three categories:

1. Non -enzyme -induced antibacterial drugs (such as amoxicillin, ammonia crickets, cephalosporine, ciprotyle, erythromycin, metronidazole, bephinomin, 土omylinin, metharochemidin);

2. It is known that enzyme -induced drugs that reduce the effect of oral contraceptives (such as Camari Ping, Grayrinin, Navella Ping, Okasipiping, Penaberbu, Penalone Sodium, Primenone, Lifepine, Lifover, LiffukiPing, Lifer Ping, Litonavvi, Topimidone);

3. Pharmaceuticals commonly used as comparison (such as Xilu Pulan, ibuprofen, Lansozole, Losenramine, decenttamine, heating polyga, Puklol, Catekine, Pippin).

Researchers compare the number of patients with accidental pregnancy, arrhythmia, headache and diarrhea in each group.

A woman with an enzyme-induced drug (OR = 13, 95%CI 5.5-31) or antibiotics (or = 6.7, 95%CI 2.9-16) has an unexpected pregnancy.

Figure 1 The chance of taking enzyme -induced drugs or antibiotics is higher

In addition, compared with the control drugs, enzyme-induced drugs also increase the possibility of congenital abnormalities (OR = 7.4, 95%CI 6.4-8.6), while the probability of using antibiotics is lower (OR = 0.71; 95%CI, 0.59 0.59-0.86), both groups have no arrhythmia, headache or diarrhea.

Researchers mentioned that women who take hormone contraceptives should realize that this contraceptive pill may become less effective. It is recommended that women who are not prepared to get pregnant to avoid sexual behavior or avoid sexual behavior or within 7 days after taking the medicine orTake additional prevention measures, such as using condoms.

Reference materials:

[1] Aronson JK, et al. BMJ Evid Based Med. 2020; Doi: 10.1136/BMJEBM-2020-111363.

[2] https://www.healio.com/news/endocrinology/20201008/study-confirms- Reduced-EFFICACY-OF-Hormonal-ContiBiBiBiBiTibiotic-Use

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